DIRECTIONS : PLEASE CAREFULLY READ ALL QUESTIONS AND ANSWER ALL QUESTIONS. OUTLINES ARE ATTACHED TO THIS POST AS A REFERENCE DUE TODAY: @ 6:00PM EASTERN STANDARD TIME 6.) The first reaction of the tricarboxylic acid cycle condenses the acetyl group, acetyl CoA with which of the following TCA cycle intermediates ? A. pyruvate B. oxaloacetate C. citrate D. malate 7.) In the TCA cycle TP is produced from CDP and Pi by which of the following mechanisms? A. substrate level phosphorylation B. cAMP- dependent kinase phosphorylation C. reverse phosphorylation 8.) Succinate thiokinase (AKA succinyl – CoA synthetase) cleaves a high energy bond CoA this high energy bond is of which of the following types ? A. Ester B carboxylic acid C.aldehyde D. thioester 9.) The primary substrate in gluconeogenesis is which of the following ? A. glicerol B. fatty acids C. amino acids D. glucose 10.)Which of the following results in a futile cycle ? A. glycolysis is inactive and glycogenesis is active B. both glycolysis and gluconeogenesis are
inactive C. both glycolysis and gluconeogenesis are active D. glycolysis is active and gluconeogenesis is inactive 11.) True/ False: Oxaloacetate is permeable to inner mitochondrial membrane A.True B.False 12.)The Cori Cycle is best described as which of the following? A. glucose converted to pyruvate and back to glucose B. glucose converted to glycogen and back to glucose C. glucose converted to ATP and back to glucose D. glucose converted to lactate and back to glucose 13.) True /False the reaction : Acetyl – CoA+ oxaloacetate -> citrate is an anaplerotic reaction A.True B.False 14.) When initial reaction velocity is plotted as a function of substrate concentration the kinetics data of non allosterically regulated enzymes generate a curve with A. linear morphology B. Hyperbolic morphology C. zero order morphology D. sigmoidal morphology 15.) Addition of a competitive inhibitor to an enzymatically catalyzed reaction will A. increase the affinity the enzyme has for its substrate B. reduce the Vmax of the reaction